What are the implications of this study for prevention?

Opioids don't work well for chronic pain and are overused, study finds

NBC News story: https://www.nbcnews.com/storyline/americas-heroin-epidemic/opioids-are-overused-they-don-t-even-work-well-study-n949466

JAMA publication abstract: https://jamanetwork.com/journals/jama/article-abstract/2718795