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This framework recognizes the critical role of public health leaders and partners in carrying out a comprehensive, cross-sector response to the opioid crisis. With effective leadership and cross-sector partnerships, states and territories can leverage four key strategies in their work, including (1) training and education; (2) monitoring and surveillance; (3) treatment, recovery and harm reduction; and (4) primary and overdose prevention. Each element of the framework was assessed for the level of evidence supporting the recommendation.
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